Pilot study: simulating myopic chromatic aberration on a computer screen induces progressive choroidal thickening in myopes
DOI:
https://doi.org/10.15626/sjovs.v17i2.4232Keywords:
myopia, emmetropization, longitudinal chromatic aberration, myopic defocusAbstract
The purpose of this study was to determine whether repeated exposure to a digitally simulated myopic chromatic aberration (“red in focus” filter) on a computer screen, can change axial length (AL) and choroidal thickness (ChT) in young human subjects.
Six myopic and four emmetropic subjects worked on a computer screen with a “red in focus” filter for 2 hours per day over 12 consecutive days (days 1–12). The treatment period was followed by 2 days of recovery where subjects performed computer work for 2 hours per day without filtering (days 13 and 14). Before and after each computer work episode, axial length and subfoveal choroidal thickness were measured in both eyes. Additionally, on days 1, 12, and 14, visual acuity and contrast sensitivity were measured in three luminance-matched light conditions: red, blue, and white light.
Myopic, but not emmetropic eyes showed progressive thickening of the choroid and shortening of the axial length over 12 consecutive days with the “red in focus” filter (AL:−31 ± 39 µm, p < 0.01; ChT: +18 ± 14 µm, p < 0.0001) with significant recovery when compared to the last days of the treatment period (AL: +10 ± 26 µm, p < 0.05; ChT:−16 ± 10 µm, p < 0.001). Visual acuity improved in both emmetropic and myopic eyes, under all light conditions, however, a significant difference was measured only in emmetropic eyes in red light (−0.03 ± 0.15 vs. −0.19 ± 0.14 LogMAR, p < 0.05). Contrast sensitivity did not significantly change during the entire experiment in emmetropic or myopic eyes.
Working on a computer screen with the “red in focus” filter may have an inhibitory effect on myopia progression since it causes progressive thickening of the choroid and associated shortening of axial length over 12 days. However, long-term studies with larger sample sizes are necessary to verify a general effect.
References
Aleman, A. C., Wang, M., & Schaeffel, F. (2018). Reading and myopia: Contrast polarity matters. Scientific Reports, 8(1), 10840. https://doi.org/10.1038/s41598-018-28904-x
Chakraborty, R., Read, S. A., & Collins, M. J. (2011). Diurnal variations in axial length, choroidal thickness, intraocular pressure, and ocular biometrics. Investigative Ophthalmology & Visual Science, 52(8), 5121–9. https://doi.org/10.1167/iovs.11-7364
Chun, R. K., Choy, K. Y., Li, K. K., Lam, T. C., Tse, D. Y., & To, C. H. (2023). Additive effects of narrowband light and optical defocus on chick eye growth and refraction. Eye and Vision, 10(1), 15. https://doi.org/10.1186/s40662-023-00332-7
Gawne, T. J., She, Z., & Norton, T. T. (2022). Chromatically simulated myopic blur counteracts a myopiagenic environment. Experimental Eye Research, 222, 109187. https://doi.org/10.1016/j.exer.2022.109187
Gawne, T. J., Ward, A. H., & Norton, T. T. (2018). Juvenile tree shrews do not maintain emmetropia in narrow-band blue light. Optometry and Vision Science, 95(10), 911–920. https://doi.org/10.1097/opx.0000000000001283
George, S., & Rosenfield, M. (2004). Blur adaptation and myopia. Optometry and Vision Science, 81(7), 543–7. https://doi.org/10.1097/00006324-200407000-00016
He, Y., Wang, Y., Wang, Z., Fang, C., Liu, Y., Zhang, L., Zheng, S., Wang, L., & Chang, S. (2013). Study on chromatic aberration in a population of Chinese myopic eyes by means of optical design. Biomedical Optics Express, 4(5), 667–79. https://doi.org/10.1364/boe.4.000667
Howarth, P. A., & Bradley, A. (1986). The longitudinal chromatic aberration of the human eye, and its correction. Vision Research, 26(2), 361–6. https://doi.org/10.1016/0042-6989(86)90034-9
Hung, L. F., Arumugam, B., She, Z., Ostrin, L., & Smith, 3., E. L. (2018). Narrow-band, long-wavelength lighting promotes hyperopia and retards vision-induced myopia in infant rhesus monkeys. Experimental Eye Research, 176, 147–160. https://doi.org/10.1016/j.exer.2018.07.004
Marcos, S., Burns, S. A., Moreno-Barriusop, E., & Navarro, R. (1999). A new approach to the study of ocular chromatic aberrations. Vision Research, 39(26), 4309–23. https://doi.org/10.1016/s0042-6989(99)00145-5
Mon-Williams, M., Tresilian, J. R., Strang, N. C., Kochhar, P., & Wann, J. P. (1998). Improving vision: Neural compensation for optical defocus. Proceedings of the Royal Society B: Biological Sciences, 265(1390), 71–7. https://doi.org/10.1098/rspb.1998.0266
Ohlendorf, A., & Schaeffel, F. (2009). Contrast adaptation induced by defocus - a possible error signal for emmetropization? Vision Research, 49(2), 249–56. https://doi.org/10.1016/j.visres.2008.10.016
Panorgias, A., Aigbe, S., Jeong, E., Otero, C., Bex, P. J., & Vera-Diaz, F. A. (2021). Retinal responses to simulated optical blur using a novel dead leaves ERG stimulus. Investigative Ophthalmology & Visual Science, 62(10), 1. https://doi.org/10.1167/iovs.62.10.1
Poudel, S., Jin, J., Rahimi-Nasrabadi, H., Dellostritto, S., Dul, M. W., Viswanathan, S., & Alonso, J. M. (2024). Contrast sensitivity of ON and OFF human retinal pathways in myopia. Journal of Neuroscience, 44(3). https://doi.org/10.1523/jneurosci.1487-23.2023
Pusti, D., Bang, S. P., Debnath, D., Patel, N., & Yoon, G. (2024). Controlling ocular longitudinal chromatic aberration and its impact on the choroidal response to signs of defocus. Investigative Ophthalmology & Visual Science, 65(7), 2715.
Schaeffel, F., & Wildsoet, C. (2013). Can the retina alone detect the sign of defocus? Ophthalmic and Physiological Optics, 33(3), 362–7. https://doi.org/10.1111/opo.12058
She, Z., Ward, A. H., & Gawne, T. J. (2023). The effects of ambient narrowband long-wavelength light on lens-induced myopia and form-deprivation myopia in tree shrews. Experimental Eye Research, 234, 109593. https://doi.org/10.1016/j.exer.2023.109593
Smith, 3., E. L., Hung, L. F., Arumugam, B., Holden, B. A., Neitz, M., & Neitz, J. (2015). Effects of long-wavelength lighting on refractive development in infant rhesus monkeys. Investigative Ophthalmology & Visual Science, 56(11), 6490–500. https://doi.org/10.1167/iovs.15-17025
Suchkov, N., Fernández, E. J., & Artal, P. (2019). Impact of longitudinal chromatic aberration on through-focus visual acuity. Optics Express, 27(24), 35935–35947. https://doi.org/10.1364/oe.27.035935
Swiatczak, B., & Schaeffel, F. (2022). Myopia: Why the retina stops inhibiting eye growth. Scientific Reports, 12(1), 21704. https://doi.org/10.1038/s41598-022-26323-7
Thibos, L. N., Bradley, A., Still, D. L., Zhang, X., & Howarth, P. A. (1990). Theory and measurement of ocular chromatic aberration. Vision Research, 30(1), 33–49. https://doi.org/10.1016/0042-6989(90)90126-6
Vinas, M., Dorronsoro, C., Cortes, D., Pascual, D., & Marcos, S. (2015). Longitudinal chromatic aberration of the human eye in the visible and near infrared from wavefront sensing, double-pass and psychophysics. Biomedical Optics Express, 6(3), 948–62. https://doi.org/10.1364/boe.6.000948
Wagner, S., & Strasser, T. (2023). Impact of text contrast polarity on the retinal activity in myopes and emmetropes using modified pattern ERG. Scientific Reports, 13(1), 11101. https://doi.org/10.1038/s41598-023-38192-9
Wang, M., Schaeffel, F., Jiang, B., & Feldkaemper, M. (2018). Effects of light of different spectral composition on refractive development and retinal dopamine in chicks. Investigative Ophthalmology & Visual Science, 59(11), 4413–4424. https://doi.org/10.1167/iovs.18-23880
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Copyright (c) 2024 Barbara Swiatczak, Lea Ingrassia, Hendrik P. N. Scholl, Frank Schaeffel
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